Mednarodni projekti
Antimicrobial endotoxin neutralizing peptides to combat infectious diseases (ANEPID)
Organizacije (1)
| št. |
Evidenčna št. |
Razisk. organizacija |
Kraj |
Matična številka |
Štev. publikacijŠtev. publikacij |
| 1. |
0104 |
Kemijski inštitut |
Ljubljana |
5051592000 |
10 |
Povzetek
Antibiotic resistant bacteria pose an increasing global threat to the fight of infectious diseases, cause considerable morbidity in Europe resulting in high economical costs. Furthermore, classical antibiotics may increase end toxin release thus promoting end toxic shock, when bacterial sepsis develops, claiming hundreds of thousands of lives yearly. To respond to the urgent need for antibiotics with novel mechanisms of action and for effective compounds to combat sepsis, we propose to design antibiotic and anti-septic drugs by modification of host defence peptides with hydrophobic chains, guided by the structure-activity relationship analysis of their biological activities, tertiary structure and biophysical analysis of peptide-membrane/end toxin interaction. The project also includes the development of large-scale synthesis strategies and the evaluation of potential side effects the candidates may have for preclinical studies.
