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Mednarodni projekti vir: SICRIS

Pt (ii) and pd (ii) complexes with oligonucleotides and dna constituents as virus inhibitors

Organizacije (1)
št. Evidenčna št. Razisk. organizacija Kraj Matična številka Štev. publikacijŠtev. publikacij
1.  0104  Kemijski inštitut  Ljubljana  5051592000  10 
Povzetek
I would like to invite you to join our research group working in the area of nucleic acids. The research is supported by the Slovenian Government Research Programme entitled: 'Synthesis and Structural Studies of Biological Macromolecules' which is tightly connected to COST-D- 20 Programme- 'Metal compounds in the Treatment of Cancer and Viral Diseases'. We can offer an excellent training in nucleoside and nucleotide chemistry having all crucial chemicals in hand. DNA synthesizer is available next to all necessary equipment for NA structure determinations. The programme is focused on higher order molecular complexes namely on hybridization studies of appropriate duplexes, triplexes and quadroplexes mainly resulted from guanine rich oligonucleotides. Pt(II) and Pd(II) interactions will be studied either with NA constituents analogues or with specially designed and targeted oligonucleotides. Excellent NMR (600 MHz), mass-spectral and X-ray facilities will be provided for. We can certainly advertise our expertise in coordination chemistry which we perform in collaboration with other members of COST -D20 action. These positions are available immediately for the periods from 3-months up to 12 months. This training is especially recommended for individuals who want to work in bio-inorganic area on biological mechanisms of platinum drugs.
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