Developement of new measuring methods in medicine and physiology Developement of original computer programs (analysis of variability of intervals in ECG in man in different diseases and normal), developement of the interactive computer model for simulation of the cardiovascular function New sientific findings (movement of the free ventricular wall in guinea pigs, changes in the left ventricular wall during sepsis in rats) Our research program was divided into 6 subfields. The results were presented in 16 scientific paper in the journals cited by SCI, 5 Ph. D. Theses and 4 Master Theses. 1. Cardiovascular dynamics: We developed a new method (video image analysis in time domain using optical markers positioned on the epicardial wall) and introduced three additional methods to study of mechanical properties of the isolated and beating (open chest preparation) guinea pig left ventricle or rats for studying epicardial strains (ultrasound crystals and volume pletismography, and a measuring technique to analyze the collagen content in the left ventricular wall during sepsis in rats). An interactive mathematical method for simulation of the cardiovascular system was developed for the purpose of analysis of the experimental data and to study its function (www2.mf.uni-lj.si/tildefizio). 2. Studies in the field of microcirculation in physiological (influence of physical exertion and local cooling on laser Doppler flow and reactivity of cutaneous microcirculation) and pathological conditions (development of hypertension, development of cold hypersensitivity in the replanted fingers) were used to elucidate mechanism of primary and secondary microvascular changes accompanying important vascular pathology, and those to elucidate one of the most important population pathology. New methods were introduced: for intradermal injection, and iontophoretic application of pharmaca to study in vivo pharmacodynamics, and to study sensitivity of baroceptive reflex. 3. Noninvasive measurement of small artery compliance, particularly its dependence on transmural pressure in the broader range of arterial pressures concerned the development of measuring methods and study of physiological and pathophysiological factors that affect reactivity of elastic and muscular component of the arterial compliance. 4. Cardiac electrophysiology concerned measurement of variability of PQ and QT intervals and study in normal and pathological conditions including coronary heart disease, age differences and postmenopausal effects in women, based on development of own measuring methods and mathematical models for understanding measuring data and in cooperation with NASA, and Texas Heart Institute, Houston, USA.