This research program has been designed and directed into the search for new principles and concepts in chemical detection and separation and into the development of novel methodologies and tools in analytical chemistry. Within this phundamental research program we achieved several high impact results that represent a significant contribution to the global science and at the same time exhibit distinct application potentialities. Below we give a condensed list of the most significant research achievements that all represent a complete novelty in their areas at a global level: (i) a cathophoresis paint insulated carbon fibre disk ultramicroelectrode (with an overall tip diameter of ca 10 mm), applicable for in-vivo measurement and research in cell physiology; (ii) an electrochemical glucose nano-biosensor with integrated micro-reference electrode (with a tip diameter of less than 500 nm); (iii) a flow injection system combined with several computer controlled pumps; (iv) a bismuth film electrode for stripping electrochemical determination of trace toxic metals; (v) a method for anion pre-concentration based on ion exchange for their determination by using capillary electrophoresis; (vi) a voltammetric microsensor for simultaneous measurement of dopamine and ascorbate at their physiological concentration levels; (vii) an algorithm for computer simulation of anion separation in ion chromatography; (viii) a pH nano-electrode based on polyaniline-coated ion beam-etched carbon fibre (with a tip diameter of less than 500 nm). In the period 1999 - 2993, based on the results achieved within this research program, the group published 39 original research papers in international scientific journals with SCI impact factor (IF), of which 33 in journals with IF higher than the mean IF in their field (IF biger than x, data taken from Cobiss). Of these, 19 articles were published in journals that take one of the first ten positions in their fields. Besides, the program team members contributed 62 oral and poster presentations at 38 international and national scientific meetings.