A basis for routine in vivo testing of potential new drugs for the treatment of venous thrombosis was developed on two venous thrombosis models in rat. Results of studies of injuries caused by hypoxia/reoxygenation on isolated hearts and isolated vessels and of possible prevention of these injuries by some protective drugs (calcium antagonists, sex hormones) might contribute to the modification/broadening of their clinical use and to the developing of new drugs. Important is also the elucidation of the role of some endogenic substances, e.g. endothelins in some physiological and patho-physiological processes as is hypoxia/reoxygenation. Our discovery of pharmacological and hypoxic preconditioning of the vessels as the possible vascular protection from hypoxia/reoxigenation will be used as prevention and treatment of some vascular dieseases in Slovenia as well as in the world. The detailed knowledge of mechanisms of acting of honey-bee venom and its components on vessels will improve the methods of immunisation and increase its safety. The study of endothelial injuries induced by some components of this venom can be used for development and application of drugs used in some vascular diseases, especially atherosclerosis. The experiments on isolated stomach and atrium are important for pharmacodynamic testing of some drugs with inhibitory effect on stomach secretion and are used in treatment of stomach ulcers. To our knowledge we are the only research group profoundly studying the influence of antidepressants on pharmacokinetics of histamine. Better knowledge of pharmacological mechanisms of antidepressants enables an easier adjustment of therapy to individual patients. Our studies demonstrate that antidepressants of different groups inhibit the increase of free histamine in circulating blood and significantly change the pharmacokinetics as well as pharmacodinamics histamine.