The results of the research program "Modelling of chemical properties and processes" are divided into three areas, according to the goals of five-years period: (i) development of chemometrics methods for various models for prediction of properties from known descriptors; (ii) investigation of structure representations and its correlation with the compounds properties as well as spectra-structure relationship; and (iii) modelling in the field of analytical chemistry to explore and better understand chemical processes involved in different analytical methods, such as FIA (Flow Injection Analysis), liquid and ion chromatography (LC, IC), and IR spectroscopy. We succeeded to get or join several European projects in the fields: distribution of knowledge of chemometrics methods and education of people from industry, research of models for assessing and prediction of toxicity of compounds, and chemometrical treatment of endocrine disrupters. The results are demonstrated in publications in journals of high quality, in organizations of workshops and conferences. We have got also the EU funding of Marie Curie training site, which enables us to accept EU students for altogether 36 months period to work on the project of chemometrical treatment of endocrine disrupters. The research of computer models for prediction of biological properties, so called "in silico" projects replace more expensive and sometimes ethically questionable "in vitro" and "in vivo" projects. The result of successful research work in the field of alternative methods (QSAR, QSPR) is an invitation on workshop ECVAM (European Centre for the Validation of Alternative Methods) in Prague, 3-4 October 2002. We presented the research "Role of QSAR in risk assessment - data sets, methods, validation of methods", which is interesting also for the Agencies for environmental protection in different counties. In the field of modelling of analytical signals we managed to solve theoretically (sistem of linear equations) and practically (computer program) the simulation of separation processes ion chromatography column.