- discovery, identification and isolation of a novel inhibitor of cysteine proteases with a completely new structure and spectre of inhibitory activity, isolated from a fungus Clytocibe nebularis. On the basis of a new membership, a novel family of cysteine protease inhibitors - mycocipins- were introduced. - development of bio test system for the determination of a sensitivity of growth and morphogenesis of Colorado potato beetle larvae. - optimisation of the isolation of selective peptides by means of high efficient bacteriophage display sistem, by using target enzymes with peptidic or non-peptidic natural substrates - determination of novel genes and their translational products for cysteine proteases from the gut of Colorado potato beetle larvae, afret feeding with the inhibitor-rih artifitial diet - identification of a novel upregulated and down regulated genes from Colorado potato beetle, after feeding with the inhibitor-rich artificial diet, by means of DNA microarray technology.