Results of our program are applicable in research and development projects of Slovenian food and analytical chemistry. Together with industry and governmental institutions we participated as principal investigators in sophisticated research and regulatory projects, which needed special knowledge and skill, mostly in the field of validation technology. We developed new original procedures for validation of industrial production lines, cleaning operations, analytical methods and products. As principle investigators we took part in analytical sections of registration documentation for pharmaceutical and food products in Slovenia and abroad. With combination of HPLC/MS/MS we solved many complicated analytical problems in pharmaceutical industry, regulatory affairs, medicine, clinical research etc. On the basis of our research we prepared new final food additives and products with increased amount of ant oxidative activities and new instrument for more reliable TLC Our work was presented in many articles and as a part of special books.. We organized International symposium of planar techniques in Novo mesto with more than 140 participants from 22 countries.