We present a simple preparation route to obtain a nanoscale metastable hard-magnetic ?-Fe2O3 phase, using silica coated ß- FeOOH nanorods as a precursor. The synthesized magnetic nanoparticles exhibit extraordinary magnetic properties confirming their high potential for practical applications. This achievement proves expertise of the project partner in the field of synthesis new nanomaterials with extraordinary magnetic properties. This material could be of high relevance for magnetic manipulation and design of extremely magnetically responsive drug delivery system. The achievement is relevant for development of advanced nanotheranostics which were the core topic of this project.
COBISS.SI-ID: 30606375
Investigation and synthesis of anisotropic magnetic nanostructures, such as wires, rods, fibers, tubes and chains, is an important field of research due to the beneficial properties and great potential for practical applications ranging from magnetic data storage to biomedicine. Silica coated iron oxide nanochains of length up to 1 µm and diameter ~80-100 nm have been synthesized by the simultaneous magnetic assembly of superparamagnetic iron oxide anoparticle clusters. We reveal that is possible to achieve either superparamagnetic or ferromagnetic behaviour with the nanochains depending only on their physical orientation. Large pore volume and pore size of silica shell as well as good colloidal stability and magnetic responsiveness of such nanochains enable their applications in biomedicine.
COBISS.SI-ID: 32059943
The development of various magnetically-responsive nanostructures is of great importance in biomedicine. The controlled assembly of many small superparamagnetic nanocrystals into large multi-core clusters is needed for effective magnetic drug delivery. Here, we present a novel one-pot method for the preparation of multi-core clusters for drug delivery (i.e., magnetic nanocarriers). The nanocarriers formed were of spherical shape, with mean hydrodynamic sizes (160 nm, good colloidal stability, and high drug loading (7.65 wt.%).
COBISS.SI-ID: 32095527
Magnetically-assisted delivery of therapeutic agents to the site of interest, which is referred to as magnetic drug targeting, has proven to be a promising strategy in a number of studies. One of the key advantages over other targeting strategies is the possibility to control remotely the distribution and accumulation of the nanocarriers after parenteral administration. However, preparation of effective and robust magnetically responsive nanocarriers based on superparamagnetic iron oxide nanocrystals (SPIONs) still represents a great scientific challenge, since spatial guidance of individual SPIONs is ineffective despite the presence of high magnetic field gradient. A strategy to overcome this issue is the clustering of SPIONs to achieve sufficient magnetic responsiveness. In this mini-review, we address current and future strategies for the design and fabrication of magnetically responsive nanocarriers based on SPIONs for magnetically-targeted drug delivery, including the underlying physical requirements, the possibility of drug loading, and the control of drug release at the targeted site.
COBISS.SI-ID: 4149873
We report on nanochains surface functionalization with amino (-NH2) and carboxyl groups (-COOH) in order to modify their surface charge. Such surfaces of nanochains provide better colloidal stability, resulting in great potential of magnetic nanochains for applications in biomedicine. The enhanced colloidal stability was con?rmed by Zeta potential (?-potential) analysis. Magnetic properties of the functionalized nanochains show superparamagnetic state at room temperature since the nanochains were composed of tiny nanoparticles as their building blocks.
COBISS.SI-ID: 32033319