The project leader dr. Petra Kocbek gave an invited lecture at 7th International BBBB Conference on Pharmaceutical Sciences. She has presented challenges and results about the development of hollow, magnetically-responsive nanostructures for drug delivery applications, which were gained in the scope of the project.
B.04 Guest lecture
COBISS.SI-ID: 4407665The achievement represents one of the 9 scientific contributions based on the results of the project (COBISS.SI-ID 31813415, 4577137, 31505959, 4565617, 31503399, 31947559, 31947815, 4425073, 29787175), which were presented at international conferences (24th Annual Meeting of the Slovenian ChemicalSociety, Portorož, Slovenia; 32nd Conference of The European Colloid and Interface Society, Ljubljana, Slovenia; The 2018 joint Meeting of the Bioelectromagnetics Society (BioEM) and the European BioElectromagnetics Association (EBEA), Portorož, Slovenia; Frontiers in Delivery of Therapeutics, Tartu, Estonia; International Conference on the Scientific and Clinical Applications of Magnetic Carriers, Copenhagen, Denmark; 5th Annual SFNano Meeting, Montpellier, France; NANOCON 2017, Brno, Chech Republick; 8th International Congress on Biocatalysis, Hamburg, Germany) during the duration of the project.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 4565617In the scope of master's thesis, we investigated physical stability of superparamagnetic iron oxide nanoparticle clusters coated with porous silica, which had the surface additionally modified with hydrophilic polymers. The modification of the cluster's surface with hydrophilic polymer improved their physical stability. The porous silica coating and the hollow core of nanoparticle clusters represent the place for incorporation of active substances. Orlistat, which exhibits anticancer activity, was used as a model drug. It was incorporated into magnetic clusters by nanoparticle incubation in ethanol drug solution. The results showed that the size of pores in the silicate coating was too small, which prevented efficient incorporation of the drug. Based on the results, we concluded that the majority of the drug has been bound on the surface of the clusters, which does not allow its controlled release. Besides Špela Hafner, Maja Avbelj has also finished her master thesis in the scope of the project (Development of a method for poorly soluble drug loading into superparamagnetic iron oxide nanoparticle clusters, [COBISS.SI-ID 4354673]). This indicates the direct transfer of the new knowledge to the young experts, who are well employable in the public (pharmacy, faculty) as well as in the economic sector (pharmaceutical industry).
D.10 Educational activities
COBISS.SI-ID: 4522097Members of the project group were members of the organizing committee of the symposium (J. Kristl, A. Zvonar Pobirk) and actively participated in the symposium as lecturers (M. Gašperlin [COBISS.SI-ID 4104049], P. Kocbek [COBISS.SI-ID 4106353] , O. Planinšek [COBISS.SI-ID 4106097], Š. Zupančič [COBISS.SI-ID 4106609]). The main topic of the symposium was the design of controlled release drug delivery systems. The symposium was organized at UL-FFA on June 16, 2016.
B.01 Organiser of a scientific meeting
COBISS.SI-ID: 4107121Object of the invention is within the scope of tissue engineering. The procedure for the establishing of the biomimetic in vitro model of bladder cancer is as follows: fluorescently labelled cancer urothelial cells are seeded on the preformed partially differentiated normal urothelial model. The biomimetic model allows monitoring the adhering of cancer urothelial cells on the surface of partially differentiated urothelium and the growing of cancer cells between normal cells in live, as well as the analysis of cellular structures after fixation and immunolabeling of the model. The present biomimetic vitro model of bladder cancer allows us to study the cell-biological mechanisms of dissemination of cancer urothelial cells, and consequently, the formation of bladder cancer. The model enables also evaluation of nanodelivery system uptake and its effects on the cells of the model.
F.33 Slovenian patent
COBISS.SI-ID: 32541401