Keynote lecture
B.04 Guest lecture
COBISS.SI-ID: 38448901PhD thesis supervisor of Aljaz Godec: "Many-body correlations in hydrophobic hydration" faculty of Mathematics and Physics, University of Ljubljana (2012), who received for his doctorate the Pregl Award from the Institute of Chemistry as well as the Golden Emblem of Jožef Stefan.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 24187883 months hosting and teaching at the Universita degli Studi di Cagliari, Dipartimento di Scienze Chimiche e Geologiche, Cittadella Universitaria di Monserrato (May-July 2013)
B.05 Guest lecturer at an institute/university
COBISS.SI-ID: 5478426PhD thesis covers the research of inhibitor binding to human and fungal CYP51 enzyme (mentor S. Golič Grdadolnik). Worldwide increase in the incidence of opportunistic fungal infections and emergence of resistance to available antifungal drugs, raise the need to develop new, more selective, and efficient inhibitors of fungal CYP51, which is a prime target for the treatment of fungal infections. The CYP51 enzymes were expressed in bacteria E. coli with our own and more efficient procedures. By application of spectrophotometric binding studies we have shown that the new types of inhibitors have strong potential for the development of selective fungal CYP51 inhibitors. For the first time the binding interactions of a CYP51 inhibitor with a different structural scaffold form azoles were determined at the atomic level. We managed this through a combination of experimental spectroscopic methods in liquids and theoretical molecular modeling methods, which is due to the internal mobility of new inhibitors, proved to be the only one suitable for the determination of their mode of binding. The results reveal the unique binding properties of the investigated inhibitors in comparison to the azoles. The structural elements and the key binding interactions responsible for the selective mode of action were determined. The results of the doctoral work represent an original contribution to the understanding of the mechanism of selective binding of inhibitors to fungal CYP51 and provide new guidelines for the design of effective and selective fungal CYP51 inhibitors with high antifungal activity against Candida species.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 278652928Novel derivatives of pyridylethanol (phenylethyl) amines were synthesized as ligands of sigma receptors. Due to inhibitory effects on the enzymes of the post-squalene part of sterol biosynthetic route pharmacologically related to sigma receptors series of compounds were further developed for inhibiting cholesterol biosynthesis in cell cultures aiming at the treatment of hypercholesterolemia and hyperlipemia in humans.
F.32 International patent
COBISS.SI-ID: 21470425