Different synthetic approaches utilizing ring-opening polymerization of N-carboxyanhydrides for the preparation of polypeptide and polypeptide-based hybrid materials with various molecular architectures are described. An overview of polymerization mechanisms using conventional (various amines) as well as some recently developed initiators (hexamethyldisilazane, N-heterocyclic persistent carbenes, etc.) is presented, and their benefits and drawbacks for the preparation of polypeptides with well-defined chain length and chain-end functionality are discussed. Recent examples from the literature are presented to illustrate the possibilities to synthesize pure polypeptide materials with different molecular architectures bearing various functional groups, which are introduced either by the modification of amino acids before they are transformed into the corresponding N-carboxyanhydrides, or by the post-polymerization modifications using protective groups and/or orthogonal functional groups. Different approaches for the preparation of polypeptide-based hybrid materials from recent literature are also discussed as well. Syntheses of simple block-copolymers or copolymers with more complex molecular architectures (graft and star copolymers) as well as various modifications of nanoparticles and other surfaces with polypeptides are described.
B.06 Other
COBISS.SI-ID: 5825818Present invention describes the synthesis of biodegradable, high-molecular weight, mono-functional PEG-polypeptide reagents with branched structure and narrow molecular-weight for the use in protein conjugation.
F.32 International patent
COBISS.SI-ID: 5813018In this presentation the synthesis, characterization and application of novel non-toxic, biodegradable and biocompatible polymer drug carriers of different architecture based on various combinations of chitosan, synthetic polypeptides and dendritic polymers were presented, i.e. poly(ester-amide) dendrimers synthesized from the AB2 adduct of 2,2-bis(hydroxymethyl)propanoic acid and glycine, alkyl-modified poly(sodium glutamates) synthesized by ring-opening polymerization of N-carboxyanhydrides and subsequent hydrophobic post-polymerization modification, and chitosan-graft-poly(sodium-L-glutamates), prepared by grafting the polypeptide grafts from the chitosan backbone. Our goal was to prepare drug delivery systems with improved properties for the delivery of poorly water-soluble, low molecular-weight active pharmaceutical ingredients in the form of solid dispersions, or for the oral delivery of high molecular-weight protein/peptide drugs (biopharmaceuticals) in the form of nanoparticles, prepared by polyelectrolyte complexation method.
B.04 Guest lecture
COBISS.SI-ID: 5595418Polyethers, polyesters and polypeptides can be synthesized by ring-opening polymerization of corresponding cyclic monomers, i.e. epoxides, lactones and N-carboxyanhydrides, respectively. Ring-opening polymerization usually results in polymers with controlled molar mass characteristics and chain-end fidelity which enable the preparation of block-copolymers and polymers with complex macromolecular architectures. Due to different reactivity of individual monomers various initiator/catalytic systems are usually required for a good control over the polymerization. In this presentation different approaches to one-pot sequential block-copolymerization of monomers with significantly different reactivity and the use of unconventional initiators will be discussed, supported by detailed characterization of macromolecular structures of the resulting polymers. Additionally, some examples of various post-polymerization modifications to prepare polymers with specific properties for biomedical applications will be presented.
B.05 Guest lecturer at an institute/university
COBISS.SI-ID: 6023194In this lecture at Graz university of technology I have presented the principles of preparation of multifunctional synthetic polypeptides with ring-opening polymerization for use in various biomedical applications. Beside the general introduction into ring-opening polymerization of N-carboxyanhydrides various examples on synthesis and characterization of amphiphilic anionic polypeptides for use in drug delivery systems as well as cationic polypeptides as new antibacterial polymers were presented.
B.05 Guest lecturer at an institute/university
COBISS.SI-ID: 6044954