Evidence has previously been demonstrated for the role of NK cells in specific elimination of healthy stem cells (e.g. hMSC, hDPSC, hESC, hiPSC) as well as cancer stem cells, but not their differentiated counterparts. We proposed that CD16+CD56dimCD69 NK cells are important for the selection of stem cells, whereas the CD 16dim/CD56dim/+CD69+anergized NK cells are important for differentiation and eventual regeneration of the tissues and the resolution of inflammation, thus potentially serving as regulatory NK (NKreg) cells. The concept of 'split anergy' in NK cells and the generation of NKreg cells with regard to contributions to cell differentiation, tissue repair and regeneration and in tumor resistance are discussed in paper.
COBISS.SI-ID: 3746673
Cysteine cathepsins are lysosomal peptidases involved at different levels in the processes of the innate and adaptive immune responses. This review is focused on the role of cysteine cathepsins and their inhibitors in the molecular mechanisms leading to the cytotoxic activity of T lymphocytes and NK cells in order to address new possibilities for regulation of their function in pathological processes.
COBISS.SI-ID: 3788913