We performed quantitative global analysis according to a model for protein interaction equilibria on a surface to obtain an estimate of a surface constant for fXa dimer dissociation approximately 10-fold lower than for fXa-fVa complex. Experiments performed using activated platelet-derived microparticles (MPs) showed that competition between fXa dimerization and fXa-fVa complex formation was even more prominent on MPs. This suggests a hitherto unanticipated mechanism by which PS-exposing platelet membranes can regulate amplification and propagation of blood coagulation.
COBISS.SI-ID: 28273959