This work focused on development of a new drug delivery system (DDS) for cetylpyridinium chloride (CPC) with potential for treating periodontal disease. Cetylpyridinium chloride is a compound with a broad antibacterial spectrum and is also a surface active agent. Controlled, local, site specific drug delivery is preferred in treatment of oral diseases and polysaccharide nanoparticles were developed as a novel drug delivery system for CPC. Polysaccharides used were alginate and pectin as negatively charged polymers and chitosan as positively charged polymer. For nanoparticle preparation three methods were tested: 1) ionic crosslinking, 2) ionic crosslinking with following polyelectrolyte complexation and 3) coating of CPC micelles with oppositely charged polymer – alginate, as a base for nanoparticle formation. The first two methods showed the formation of aggregates after approximately one hour after preparation. Method 3 enabled preparation of stable alginate-CPC nanoparticles, which was proved by photon correlation spectroscopy and atomic-force microscopy.
D.10 Educational activities
COBISS.SI-ID: 3909745The European Journal of Pharmaceutics and Biopharmaceutics provides a medium for publication of novel and innovative research from the areas of Pharmaceutical Technology, Pharmaceutical Biotechnology and Biopharmaceutics.
C.06 Editorial board membership
Journal of Biomedical Nanotechnology is a multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
C.06 Editorial board membership