This paper presents objective follow up after treatment of retinal vein occlusion with bevacizumab. Results were encouraging, showing that retina recovers layer by layer.
COBISS.SI-ID: 1719468
Purpose: Diabetic retinopathy (DR) has features of chronic low-grade inflammation. The purpose of our study was to investigate whether the presence of inflammatory cells in fibrovascular membranes (FVMs) from patients with proliferative diabetic retinopathy (PDR) is associated with the activity of PDR and visual acuity improvement after vitreoretinal surgery. Methods: 40 FVMs from 40 patients with PDR were obtained during vitrectomy, prepared by using the agar sandwich method and examined using light microscope and immunohistochemistry methods to define the presence and density of inflammatory cells: CD45+ cells (leukocytes), CD4+ cells (T helper lymphocytes), CD8+ cells (T cytotoxic lymphocytes), CD19+ cells (B lymphocytes) and CD14+ cells (monocyte/macrophage). For each FVM, the inflammatory cell density defined as numerical areal density was calculated. The number of vessels was defined as the volume density of vessels. Results: Among 40 patients with PDR, 33 patients had active PDR, and 7 quiescent PDR. Significant differences in cell densities for CD4+, CD8+ and CD19+ cells were observed between patients with active and quiescent PDR. B lymphocytes were present in membranes of active PDR only. No correlation was observed between numerical areal density of inflammatory cells, and the volume density of vessels. No association was found between visual acuity improvement after surgery and cell densities. Conclusion: Lymphocyte infiltration of FVMs might be associated with the activity of retinopathy but not with visual acuity improvement after surgery.
COBISS.SI-ID: 1882028
This paper describes new genetic mutations in mitochondrial genome in LHON as well as clinical and electrophysiological data in Slovenian patients with this disease.
COBISS.SI-ID: 2120364
This paper brings the results of international multicentric study that brings results of treatment of visual field after treatment with Vigabatrin.
COBISS.SI-ID: 1719212
The purpose of this study was to evaluate color vision in young patients with demyelinating disease both clinically and electrophysiologically. Thirty young patients (8-28 years, mean age 19 years) with demyelinating disease with or without a history of optic neuritis (ON) were investigated. Color vision was evaluated clinically with the Ishihara test and the Farnsworth-Munsell 100 hue (FM 100 hue) test and electrophysiologically with chromatic visual evoked potentials (cVEPs). Color deficiency axis and error score (ES) obtained with the FM 100 hue test were analyzed. cVEPs to isoluminant red-green (R-G) and blue-yellow (B-Y) stimuli were recorded. The stimulus was a 7 deg circle composed of horizontal sinusoidal gratings with a spatial frequency of 2%cycles/deg and 90% chromatic contrast. Onset-offset mode of stimulation (ON:OFF=300%700%%ms) was used. Since the majority of the patients were adults ()18%%years), the negative wave (N wave) of the cVEP respones is the prominent part and therefore was analyzed. Sixty eyes were studied-22 with at least one episode of ON (ON group) and 38 without any clinically evident episode of ON (nON group). The average ES in the ON group was 179.18%171.8, whereas in the nON group it was 87.60%65.34. The average N-wave latency in the ON group was 144%44%%ms for the R-G stimulus and 146%56%%ms for the B-Y stimulus, whereas in the nON group, it was 117%13%%ms for the R-G stimulus and 121%22%%ms for the B-Y one. The average N-wave amplitude in the ON group was 9.3%7.1%%%V for the R-G stimulus and 5.1%3.9%%%V for the B-Y one, whereas in the nON group, it was 10.8%8.3%%%V for the R-G stimulus and 6.4%4.3%%%V for the B-Y one. A significant difference between the ON and the nON group was found: in the ON group, ES was higher (p=0.01) and N-wave latency was longer (p=0.01) compared with those in the nON group. The study showed that color vision is expectedly more affected in the ON group, but also often in the nON group, which may indicate increased parvocellular visual pathway vulnerability in demyelinating diseases.
COBISS.SI-ID: 1432748