All organisms are made of cells that are enclosed by a highly dynamic cellular structure called plasma membrane. Besides lipids, the plasma membrane contains numerous proteins, which perform specific tasks that are crucially important for individual cell and organism’s survival. To be functional, proteins have to be properly synthesized, processed, delivered to appropriate domains of the plasma membrane and removed when they are damaged. Microscopy has contributed fundamental knowledge of these processes in the past. The aim of the talk is to present microscopic techniques currently used at the Institute of Cell Biology, Faculty of Medicine, that enable tracing transport of membrane proteins in the living cells and their localization at the ultrastructural level. On the urothelial (epithelium of the urinary bladder) model systems it will be shown how combining information obtained by light and electron microscopes gives advanced insight into function of the plasma membrane. The importance of our basic-research findings for human health will be presented.
B.04 Guest lecture
COBISS.SI-ID: 31988441Regenerative medicine combines knowledge from different fields of science with the aim to repair or improve the function of the old, damaged or pathologically changed tissues or organs. Although the first recorded examples of the use of regenerative medicine dates back more than 1,000 years, the clinical use in the laboratory established tissues and organs is still at an early stage. In the future, the only scientifically substantiated findings and clinical objectivity will ensure successful use of regenerative medicine in various fields of medicine and significantly contribute to an improved life of patients. At the lecture and workshop, the different approaches based on cells, scaffolds or tissue engineering, which are used in regenerative medicine were presented. With the help of examples the latest findings on the use, effectiveness and limitations of the various approaches in regenerative medicine were demonstrated.
B.04 Guest lecture
COBISS.SI-ID: 32165337'Cell biology' is a basic textbook for Cell biology course at the Faculty of Medicine, University of Ljubljana. It presents an overview of the cell structure and function, which gives students the basis to understand the functioning of normal and diseased organisms. The basic concepts of genetics are included, which enable rapid diagnostics and medical treatment of numerous hereditary diseases. The textbook gives the insight into methods used in biomedical sciences and genetics. Selected points of interest for medicine are discussed and some cases from clinical praxis are covered within each chapter.
D.10 Educational activities
COBISS.SI-ID: 281399808In the last 25 years widespread use of PSA caused a stage migration of prostate cancer towards localized disease at diagnosis, which resulted in transrectal ultrasound biopsy to become standard in clinical practice. Transrectal ultrasound examination of the prostate is used to diagnose benign prostatic diseases, e.g. benign prostatic enlargement, prostatitis, prostatic and seminal vesicle cysts. It is also important in the detection of obstructive causes of male infertility. Transrectal ultrasound examination is performed most often in needle biopsy for prostate cancer diagnosis. Besides guiding systematic tissue core biopsy, characteristic ultrasound changes facilitate target biopsies of suspect areas. The article describes indications, contraindications, antibiotic prophylaxis, various biopsy templates and complications of the needle biopsy. Experience with transrectal ultrasound-guided biopsy at the Department of Urology of the University Medical Centre in Ljubljana is presented.
F.01 Acquisition of new practical knowledge, information and skills
COBISS.SI-ID: 2800300Bladder (ISSN 2326-9901) is an international, open-access journal committed to publishing top-quality peer-reviewed articles describing basic laboratory, translational, and clinical investigations in the broad fields of bladder biology and diseases, including benign and malignant conditions. Subject areas covered by Bladder include, but are not limited to: anatomy, embryology, development, physiology, neurophysiology and diseases of the bladder and its neighbouring organs such as the urethra, ureters, seminal vesicle and pelvic floor.
C.04 Editorial board of an international magazine