Dr. Andrej Perdih was a supervisor of the Matej Janežič, M. Pharm. for his with Krka Prize awarded research work: In silico design and evaluation of 1H-indazole inhibitors of the human toposiomerase II[alpha].The research work included also MMT citotoxcitiy measurements performed in the scope of the ARRS bilateral project with UM Ann Arbor. MI. Matej Janežič now continues his PhD studies at the prestigious RIKEN Institute in Japan in the new group further collaborates with the project leader on topo II alpha inhibitor design.
E.01 National awards
COBISS.SI-ID: 6022426In the scope of the subject Pharmaceutical Chemistry III, part of the undergraduate curriculum at the Faculty of Pharmacy, University of Ljubljana the textbook Medicinal chemistry III: laboratory practice and seminars was published. Personal contribution chapter: Introduction to Molecular Modeling.
D.10 Educational activities
COBISS.SI-ID: 252671232The importance of research practiced by the group group draw considerable attention of the leading Slovenian newspaper ("Delo") that published an extensive interview about our simulations of enzymatic reactions which represent a source of neurodegenerative diseases and neuropsychiatric disorders. We stressed the importance of simualtion techiques capable of predicting the activity of mutated enzymes and their use in precision medicine.
B.06 Other
COBISS.SI-ID: 5878554Program group members supervised a research project of Domen Pregeljc, a student of the Gimnazija Vič high school. The prject elucidated the effect of point mutation of MAO B enzyme on the decomposition rate of neurotransmitters. The research confirmed the predicting power of simulation method and their potential use in precision medicine, particularly in the context of neuropsychiatry and neurodegeneration. Domen contested with his project at three international research olympiads, winning two silver and one gold medal. At the GENIUS olympiad (Oswego, NY, USA) he was the absolute winner. His successes greatly contributed to the general public interest in topics related to neuroscience and molecular simulation. We thoroughly presented our research in a popular show at the national radio.
B.06 Other
COBISS.SI-ID: 6321946The program group member presented the EVB methodology and its applications to enymatic reactions at a scientific conference. He also organized a workshop on EVB simulations for the students and potential users.
B.04 Guest lecture
COBISS.SI-ID: 5822746