Substituted arylsulfonamides received considerable attention as NaV channel modulators and are described in several patents published in recent years with potencies in nanomolar range. The design of the present series of compounds was based on arylsulfonamide-class of NaV channel modulators with IC50 values on human NaV1.3 channels in low nanomolar range. NaV1.3 channels are mainly expressed in the central nervous system and a number of preclinical studies have implicated their roles in nociceptive processing. In the present study, we have designed a series of substituted aminobenzenesulfonamides and evaluated their effects on human NaV1.3 channels. The obtained results provide valuable information on structure-activity relationships and are good starting points for structure based design of selective NaV modulators.
B.06 Other
COBISS.SI-ID: 3824753