The effects of intracoronary transplantation of CD34(+) cells on myocardial perfusion in patients with nonischemic dilated cardiomyopathy (DCM) were investigated. CD34(+) cell transplantation led to improved myocardial perfusion in patients with nonischemic DCM. Patients with less severe myocardial perfusion defects at baseline may had an increased likelihood to respond to intracoronary CD34(+) cell transplantation.
COBISS.SI-ID: 2346156
Our objective was to determine whether baseline differences in circulating immunologic and nonimmunologic biomarkers may help to identify patients more likely to respond to intramyocardial injection of CD34+-based stem cell therapy. We identified 9 baseline factors that were associated with both stem cell response and stem cell retention. Among the baseline factors positively associated with both clinical response and stem cell retention were G-CSF, SDF-1, LIF, MCP-1, and MCP-3. Among baseline factors negatively associated with both clinical response and retention were IL-12p70, FASL, ICAM-1, and GGT.
COBISS.SI-ID: 2448300