The effects of transendocardial CD34(+) cell transplantation in patients with ischemic cardiomyopathy were investigated.Conclusions: Transendocardial CD34(+) cell transplantation may be associated with improved left ventricular function, decreased N-terminal pro B-type natriuretic peptide levels, and better exercise capacity in patients with ischemic cardiomyopathy. These effects seem to be particularly pronounced in patients receiving diffusely distributed cell injections and high-dose cell therapy.
COBISS.SI-ID: 1661612
Background: We analyzed electromechanical mismatch (EMM) and its relationship to ventricular repolarization in patients with nonischemic dilated cardiomyopathy (DCM). Methods and Results: In 39 DCM patients with left ventricular ejection fraction (LVEF)!40% and New York Heart Association functional class$III, electroanatomic mapping was used to quantify areas of EMM. High-resolution electrocardiograph was used to measure heart rate variability (HRV) and QT variability index (QTVI). EMM was present in 22 patients (56%, group 1), whereas 17 patients presented no mismatched segments (44%, group 2). The groups did not differ in age (56610 years in group 1 vs 5767 years in group 2; P 5 .82), sex (male: 82% vs 94%; P 5 .40), LVEF (27,6 8% vs 25,6 6%), or N-terminal proe B-type natriuretic peptide (2,350 pg/mL vs 2,831 pg/mL). Although heart rate and HRV were similar in both groups (rate: 80 6 20 beats/min in group 1 vs 74 6 19 beats/min in group 2 [P 5 .47]; standard deviation of normal-to normal RR intervals: 106 6 79 vs 88 6 115 [P 5 .61]), we found significantly higher QTVI values in patients from group 1 (1.15 6 0.46 vs 1.62 6 0.51 in group 2; P 5 .005). In patients with implantable cardioverter-defibrillators, ventricular arrhythmias recorded #1 year before enrollment were more frequent in group 1 than in group 2 (58% vs 13%; P 5 .02). Conclusions: EMM is present in a majority of patients with DCM and is associated with ventricular repolarization instability.
COBISS.SI-ID: 31857881