Stem cell therapy is emerging as a potential new therapy for patients with advanced heart failure. In recent years, advances in molecular imaging have allowed monitoring of stem cell homing and survival. In this review article, we will discuss the clinical application and future directions of stem cell imaging in advanced heart failure.
F.01 Acquisition of new practical knowledge, information and skills
COBISS.SI-ID: 1267628The term advanced therapies describes the cell therapy, tissue engineering and gene therapy. Cell therapy is the treatment with autologous or allogeneic cells that if transplanted, they can replace missing or diseased cells or their components, or achieve specific therapeutic effects (eg. changes in the immune system, or attack onto the cancer cells). The most prevalent form of the stem cell transplant are haematopoietic stem cells, which are used for treatment of mainly hematological diseases. As a source of hematopoietic stem cells in the peripheral blood largely replaced bone marrow. This paper deals with every advanced therapies and clinical cases of states effective treatment.
B.04 Guest lecture
COBISS.SI-ID: 30934489In our study, autologous CD34+ haematopoietic progenitors intended for the myocardial regeneration were collected after mobilization with G-CSF, then the CD34+ fraction was enriched and collection efficiency was evaluated. The average of CD34+ cells recovery after immunomagnetic separation was 63%±22, cell purities (%CD34+/%CD45+) increased from 0.7%±0.3 to 62%±35 after enrichment. A final average dose was 109 x 10E6 cells/product. The average viability of CD34+ cells in our cell products prepared for implantation was as high as 97%. CONCLUSION: Our protocol is suitable for further clinical application based on high enrichment of the target CD34+ cell population.
F.01 Acquisition of new practical knowledge, information and skills
COBISS.SI-ID: 30574809