Stem cell therapy is emerging as a potential new therapy for patients with advanced heart failure. In recent years, advances in molecular imaging have allowed monitoring of stem cell homing and survival. In this review article, we describe the clinical application and future directions of stem cell imaging in advanced heart failure.
F.21 Development of new health/diagnostic methods/procedures
COBISS.SI-ID: 1267628The electromechanical mismatch (EMM) and its relationship to ventricular repolarization in patients with nonischemic dilated cardiomyopathy (DCM) was analyzed. Conclusions: EMM is present in more then half of dilated cardiomyopathy patients, is associated with higher QT variability, and higher ventricular arrhythmia risk.
F.21 Development of new health/diagnostic methods/procedures
COBISS.SI-ID: 31857881Our objective was to determine whether baseline differences in circulating immunologic and nonimmunologic biomarkers may help to identify patients more likely to respond to intramyocardial injection of CD34+-based stem cell therapy. We identified 9 baseline factors that were associated with both stem cell response and stem cell retention. Among the baseline factors positively associated with both clinical response and stem cell retention were G-CSF, SDF-1, LIF, MCP-1, and MCP-3. Among baseline factors negatively associated with both clinical response and retention were IL-12p70, FASL, ICAM-1, and GGT.
F.22 Improvement to existing health/diagnostic methods/procedures
COBISS.SI-ID: 2448300Parameters associated with poor CD34(+) stem cell mobilization in advanced chronic heart failure (CHF) patients were investigated. Significant differences between poor and good mobilizers were found regarding NT-proBNP levels and red cell distribution width (RDW). Increased RDW was the only independent predictor of poor CD34(+) stem cell mobilization on multivariable analysis and may serve as a biomarker of poor stem cell mobilization in CHF patients.
F.22 Improvement to existing health/diagnostic methods/procedures
COBISS.SI-ID: 2506412We evaluated the association of diabetes and insulin resistance (IR) with the response to cell therapy in patients with nonischemic dilated cardiomyopathy (DCM). Transendocardial CD34+ cell therapy appears to be ineffective in DCM patients with diabetes. IR was associated with improved CD34+ stem cell mobilization and a preserved clinical response to cell therapy.
F.22 Improvement to existing health/diagnostic methods/procedures
COBISS.SI-ID: 32541145