In this study, we characterized the S-layer protein A (SlpA) of animal and human strains belonging to different PCR-ribotypes (PR) and compared the in vitro adherence and in vivo colonization properties of strains showing different SlpA variants. Adhesion assays indicate that C. difficile strains vary in their capacity to adhere to cells in culture and that adhesion seems to be independent of the SlpA variant. Colonization properties were assessed in vivo using a dixenic mouse model of colonization. One of the strains had advantage in colonizing the intestinal mice niche.
COBISS.SI-ID: 512343352
Publication includes advanced analysis approaches on C. difficile related data in which two researchers of actula project have previously collaborated (Rupnik, Džeroski).
COBISS.SI-ID: 16731158