This paper describes a new monolithic support with a histamine ligand that can be used as a multimodal ion-exchange and hydrophobic support. An application for the plasmid DNA purification in one step is presented.
COBISS.SI-ID: 4263544
A reversible entrapment of the OC form of plasmid DNA within the monolithic structure is described together with the presentation of the ways how to overcome these limitations.
COBISS.SI-ID: 2899451
A novel mixed-mode grafted monolithic chromatographic support containing ion-exchange and hydrophobic groups is presented. Preparation and characterization of the novel material is described and the application for the plasmid DNA isolation is discussed.
COBISS.SI-ID: 4199288
Theoretical considerations of the separation of large biomolecules under the conditions of a linear gradient elution on the monolithic chromatography media are presented and elaborated.
COBISS.SI-ID: 4263032
The paper gives an overview on the virus particle production challenges and chromatography based analytical methods for efficient monitoring of the virus production, covering also methods developed in the programme.
COBISS.SI-ID: 4534648