In cooperation with the Blood transfusion centre of Slovenia, we have developed a prototype for a product intended for advanced therapies. The product encompasses the use of dendritic cells as negative vaccines for the treatment of those immune-mediated diseases which are characterized by excessive and harmful activity of the immune system. The preparation of the product encompasses ex vivo differentiation and modification of dendritic cells in a way, that these cells act in an immunosuppressive manner. This kind of product is useful in treating diseases, characterized by too strong and unwanted immune reactions like autoimmune diseases and allogeneic transplantations.
F.08 Development and manufacture of a prototype