During intensive studies, which led to the proposed invention, the inventors have discovered, that we can speculate on the potential agonsim/antagonism or the intrinsic activity of synthetic DC-SIGN inhibitors using a method, which ensures culturing of dendritic cells in the presence or absence of synthetic DC-SIGN inhibitors along with or without the addition of TLR agonists. Therefore, the proposed invention presents a method for determining the intrinsic activity of synthetic DC-SIGN inhibitors based on the modulation of dendritic cells' cytokine profile in the presence or absence of TLR agonists. The proposed invention also ensures the use of this method for determining the intrinsic activity of synthetic DC-SIGN inhibitors for purpose of design and synthesis of novel synthetic DC-SIGN inhibitors. In addition, the proposed invention ensures the use of this method to evaluate the therapeutic potential of synthetic DC-SIGN inhibitors as antimicrobial agents.
F.33 Slovenian patent
COBISS.SI-ID: 3212145