The invention solves implementation of autonomous integrated wearable transdermal drug delivery microdosing system comprising integrated dosing micropump, collapsible reservoir with non-return filling valve, silicon hollow microneedle array injection chip and microfluidic connections. Microdosing system is attached to the skin with patch adhesive layer. Fabrication materials include but are not limited to elastomer, glass, silicon and piezoelectric material. Microfluidic elements are covalently bonded (no adhesive layer) and fabricated on biocompatible materials.
F.33 Slovenian patent
The first part of the invited lecture provides overview of some important micromachining processes and related microstructures which are constitutional structures used for sensing and actuating. The limitations of certain technological approaches are discussed and explained.The second part of the presentation is dedicated to thin film Ti/Pt temperature sensors and microheaters with emphasis on microstructural properties, which affect the electrical resistance. Characterization methods are presented for extraction of TCR and dependency on the thermal annealing parameters. The fabrication process steps provide insight into the integration of temperature sensors and heater on Si platform for microreactor applications. Last part of the presentation focuses on the piezoresistive pressure sensor structure, giving detailed analysis of membrane fabrication process and important mechanical stress issues regarding the thin film deposited layers on the membrane.
B.04 Guest lecture
COBISS.SI-ID: 9562708R&D activities in LMSE with the emphasis on their applicability in Slovenian industry as well as in Slovenian craft activities were presented. The main stress was given on advanced technologies from the field of MEMS, which add values to modern microstructures, sensors and actuators.
F.18 Transfer of new know-how to direct users (seminars, fora, conferences)
COBISS.SI-ID: 11767835A modification of microthrottle (MT) pumps by geometry modifications of actuator (piezoelectric), membrane and cavity is proposed. One of the advantages of this approach is possibility of stacking the micropumps in parallel which would make this type of pumps appropriate for complex lab on chip devices, requiring simultaneous and separate pumping of several liquids. As a strong support in micropumps design and fabrication, a complete electro–fluid–solid mechanics coupling model for numerical simulation of strip type piezoelectric micro pump has been developed using finite element analysis software COMSOL Multiphysics V4.2. Numerical simulations revealed that although during one period of sinusoidal excitation period the pumped liquid volume is flowing in both directions, the net fluid volume at output after one period is nonzero (positive), resulting in successful fluid pumping. Fabricated prototype micropumps confirmed this conclusion.
F.18 Transfer of new know-how to direct users (seminars, fora, conferences)
COBISS.SI-ID: 9419092The paper reports on investigations of transdermal drug delivery system, based on silicon injector chip with silicon microneedles and PZT actuated micropump, for drug delivery such as insulin. First, basic skin properties and dosing requirements are reviewed. Next, the whole system and its basic components (injector chip, micropump, drug container) are discussed. Based on this, microneedle injector chip design and fabrication is proposed and realized. Following is the design and fabrication of PZT actuated micropump and fluidic parameters evaluation of fabricated micropumps. Basic requirements for drug container, control electronics and power supply parameters are presented next. Finally, maximum drug liquid flow, based on measured prototype micropump parameters, through the prototype injector chip is determined.
F.18 Transfer of new know-how to direct users (seminars, fora, conferences)
COBISS.SI-ID: 9524820