Exposing biological cells to sufficiently strong external electric fields causes electroporation of cell membranes. The main advantages of irreversible electroporation over other ablation techniques are its non-thermal nature and consequently fast tissue regeneration.We show that it is possible to reduce tissue heating during the optimization procedure by penalizing higher temperatures in the objective function. We also show that optimization of electroporation parameters takes too much time when an accurate calculation of the temperature distribution is performed for each set of parameters. Instead, we propose that heating during electric pulse delivery is only conservatively estimated in the optimization procedure, while an accurate calculation is performed only when the conservative estimate implies the possibility of thermal damage.
F.10 Improvements to an existing technological process or technology
COBISS.SI-ID: 8417876