P.I. was an invited speaker at the 16th World Congress on Advances in Oncology, where she presented data on progesterone metabolism in endometriosis. Progesterone metabolism in uterine diseases has not yet been studied. In normal endometrium progesterone exerts a protective role, however studies in breast cancer show that progesterone metabolites stimulate proliferation and thus promote carcinogenesis. The P.I. showed data on progesterone metabolism in the endometriosis model cell line, where formation of pro-proliferative 5alpha-pregnanes was observed, and the stimulative effects of this metabolites were confirmed. Results presented at this meeting will contribute to a better understanding of the pathogenesis of endometriosis and the identification of novel approaches for treatment.
B.04 Guest lecture
COBISS.SI-ID: 29180633Neli Hevir studied expression of genes of estrogen and progesterone metabolism in endometrial cancer and endometriosis at the mRNA, protein and cellular levels. The results of her Ph.D. thesis show that in endometrial cancer estrogens are formed from estron-sulfate via the sulfatase pathway; while in the pre-cancerous endometrium phase I estrogen metabolism forming carcinogenic metabolites is prevalent. Her data show the dual role of estrogens in endometrial cancer: in pre-cancerous endometrium they stimulate carcinogenesis, while in cancerous endometrium they promote proliferation of previously transformed cells. Her Ph.D. thesis encompasses 4 manuscripts in journals with impact factor and 2 papers in preparation. This work enlightens new potential drug targets and suggests novel options for treatment.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 258770688Since 1. 1. 2009 P.I. is a member of the Editorial board of the Journal of Steroid Biochemistry and Molecular Biology, with I.F. 2.886.
C.06 Editorial board membership
COBISS.SI-ID: 527636