Despite numerous studies, the role of separate domains of TLR4 in the regulation of receptor activation is poorly understood. Authors proved that TLR4 represents a receptor with low threshold of activation, which can be rapidly activated by the release of inhibition exerted by its ectodomain. This is important for the sensitivity of TLR4 to activation by different agonists. TLR4 ectodomain has multiple roles in enabling ligand regulated activation, providing proper localization, while serving as an inhibitor to prevent spontaneous, ligand independent dimerization.
COBISS.SI-ID: 4652570