In the invited lecture in the frame of the workshop Nanoscience, we have presented the work on synthesis and applications of different nanostructured magnetic materials. We have reported also on the successful work we did on the Fe-Pd system for biomedical applications.
B.04 Guest lecture
COBISS.SI-ID: 27800871With the electrodeposition method we were able to construct a controllable and reproducible system that resulted in Fe-Pd nanowires with consistent composition and can be thus applied in many future magnetic applications. Further on, among many methods, electrodeposition methods is the most cost efficient method and it enables the deposition of many nanowires at the same time in contrast to others methods, and also it resulted in the highest magnetic properties for the Fe-Pd alloys.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 276909568On biomedical conference BioNanoMed we have reported on achievements with regards to the electrochemical deposition of Fe-Pd based nanostructures including tubes and wires. Tubes were successfully modified with a model drug paracetamol while Fe-Pd nanowires with the avstenite crystal structure necessary for potential magnetic shape memory effect were successfully incorporated into silica xerogels together with a model drug rhodamine B-dye. A controlled release rates were achieved with addition of reducing agent.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 26694951We reported on chemically ordered and disordered Co-Pt and Fe-Pd nanostructures which represent a promising magnetic storage media and potential as nano- and micro-magnets which can be used in micro- and nano-systems. Co-Pt and Fe-Pd-based nanotubes and nanowires produced via template assisted electroplating were discussed from the magnetic properties point of view, with the emphasis on the composition, morphology and the crystal structure influence, with a successful transformation to avsenite achieved via thermal training. Furthermore the magnetic shape memory Fe70Pd30 nanostructures were assessed as a potential smart drug delivery system, which was tested in-vivo on zebra fish models.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 27455015Drug delivery systems based on mesoporous silica nanoparticles (MSNs) have received much attention recently. Biocompatibility, chemical stability, ease of functionalization and porosity have attributed to the popularity of MSNs. Functional groups on surface allow stimulus-induced release of the cargo with zero premature release. In this regard glutathione is an important stimulus since the difference between intracellular and extracellular concentration allow drug release only inside cells. Moreover, the ability to deliver a significant amount of drug in a specific environment is an important prerequisite to prevent severe side effects. Selective targeting of delivery systems towards cancer cells is possible via their overexpressed folate receptors. Herein we present a novel type of functionalized MSNs able to incorporate targeting ability towards specific cells and release the drug upon endogenous stimulus with activation of the nanovalve. We synthesized fluorescent dye loaded MSNs (100 nm). Next, dendrimers were attached to the mesopore openings to act as a stopper and prevent leakage of the dye. The outer surface of particles was decorated with folic acid moieties providing affinity to folate receptors. Upon the addition of reducing agent the dendrimers detached and released the dye. In conclusion we have synthesized target selective MSNs with the ability to safely transport drug avoiding its premature release. Drug release is enabled only upon biological stimulus.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 36964101