Several graduate works (diplomas) were prepared on the project topic (under the supervision of involved researchers). Among these we would expose the work of Žiga Ude who prepared a number of interesting ruthenium compounds that are now studied further. We would stress that the student later started his Ph.D. studies at Royal College of Surgeons in Ireland (RCSI, Dublin) under the supervision of Dr. C. Marmion.
D.10 Educational activities
COBISS.SI-ID: 35605509Researchers Jakob Kljun and Iztok Turel held a lecture (a scientific conference contribution was also included in the book of abstracts) in which the past and current research of the research group was presented. The lecture included the presentation and discussion about the synthesis, physicochemical charaterization and preliminary biological evaluation of ruthenium coordination compounds. The emphasis was on the influence of the changes in coordination sphere of ruthenium on the biological properties of ruthenim complexes. The aim of the lecture was also to inform the professional audience with the newest results from the coordination chemistry field.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 36196869Young researcher Rosana Hudej successfuly finished her Ph.D. study on electrochemotherapy with ruthenium compounds in vitro and in vivo. The supervisors of her work were professors I. Turel and M. Čemažar who are also members of project group. It is worth to note that later R. Hudey was employed in the Bia company but was still involved in the work in our project.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 262225408I was asked by journalist Štefan Kutoš to present my research work on metal complexes.
B.06 Other
COBISS.SI-ID: 36690949Conjoint liquid chromatography (CLC) on monolithic convective interaction media (CIM) disks coupled on-line to UV and inductively coupled plasma mass spectrometry (ICP-MS) detectors was used in speciation analysis of Pt in human serum spiked with Pt-based chemotherapeutics. CIM Protein G and CIM DEAE disks were assembled together in a single housing forming a CLC monolithic column. Such a set-up allows rapid two-dimensional separation by affinity and ion-exchange (IE) modes to be carried out in a single chromatographic run. Separated Pt species were quantified by post-column isotope dilution—ICP-MS. The method developed may be reliably applied in preclinical and clinical studies of the kinetics of the interaction and distribution of different metallodrugs with proteins in blood serum.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 27382311