Controversy exists over the significance and even the existence of post-Lyme disease symptoms because of the high rate of similar background symptoms in the general population. A European, prospective clinical trial in which doxycycline and cefuroxime axetil were compared in the treatment of adult patients with erythema migrans included a control group to address this question. The frequency of nonspecific symptoms in patients did not exceed that of a control group at 6 months and later after enrollment. We advocate inclusion of appropriate non-Lyme disease control groups in future studies.
COBISS.SI-ID: 26384857
Limited data exist on differences of erythema migrans patients with either positive or negative Borrelia burgdorferi sensu lato skin culture. Evaluations of epidemiological, clinical, and microbiological findings were conducted in 159 culture positive and 101 skin culture-negative patients treated with standard antibiotics. Although findings for the pretreatment characteristics were comparable between the erythema migrans skin culture-positive and culture-negative patients, some parameters indicate that borrelia skin culture positivity may predict a less-favorable treatment outcome.
COBISS.SI-ID: 27657433