This study is a result of a collaborative study between Faculty of Pharmacy and Department of Oncology of Paediatric clinic in Ljubljana. Here we report on the role of polymorphic 5, 10-methylenetetrahydrofolate reductase (MTHFR) on relaps of Acute lymphoblystic leukemia pediatric patients.
COBISS.SI-ID: 2520433
We demonstrate the correlation of toxic effect of Thiopurine therapy with polymorphisms in genes coding for TPMT, MTHFR and TYMS. The study demonstrates the need for developing pharmacogenomic strategies of metabolic networks, instead of pharmacogenetic approaches addressing the issue of correlation of polymorphisms in a single gene with a observed complex effect of a given medicine.
COBISS.SI-ID: 2739825