The purpose of this study was to find novel genes involved in the development lung tumours. Using DNA microarrays, we identified up-regulated and down regulated genes in lung tumours. Our findings complemented a proposed VIPR1 tumour suppressor role in lung tumourigenesis, in which deletions in the 3p22 chromosome region are an important mechanism leading to loss of the VIPR1 gene.
COBISS.SI-ID: 26449625
On the conference we presented methodology for microarray procedure, analysis of the results and conclusions of the study made on lung tumours and adjacent normal tissue. Gene expression profile was significantly different in specific tumour histotype. Microarray analysis was followed by qPCR validation, with which we discovered specific genes, with differences in expression, significant in tumours.
COBISS.SI-ID: 26767065