In preparation is the chapter named LexA regulatory system for the second edition of "Encyclopedia of Biological Chemistry" published by Elsevier. An invitation from Nancy L. Craig (Howard Hughes Medical Institute).
We provide insight that LexA conformations affect RecA-mediated cleavage, therefore affect activation of the SOS response. Results explain how precise timing and duration of the stress induced genes occures in response to DNA damage. Our results serve as a starting point to develop a drug or a co-drug used with other agents.