Background: End-stage renal disease is often associated with altered bone metabolism, low bone mass and skeletal fragility. The purpose of this study was to determine bone mineral density (BMD), how BMD is changing in time and factors associated with BMD. Methods: 47 subjects undergoing HD treatment were included in this prospective clinical study. We measured BMD at left femoral neck (FN), total hip (TH) and at lumbar spine (LS) and repeated measurement after 20,9 +/- 4,5 months using a Explorer densitometers - a third generation of densitometers based on dual-energy X-ray absorptiomentry (DXA). Results: Using WHO criteria as a cutoff point, in the first measurement of BMDT-score lower than -1 was found in 67% of patients at FN, 64% at TH and 50% at LS. T-score lower than -2,5 was found in 27%, 16% and 22%, respectively. We have found a positive correlation between BMD at LS and weight (p=0,009) and a negative correlation between age and BMD at FN (p=0,017). PTHi correlated positively with longitudinal changes in BMD at LS (Rho=0,36; p=0,015) and TH (Rho=0,49; p=0,001). There was significant decrease in BMD at LS in patients with PTHi ( 100 pg/ml. Conclusions: BMD was lower at FN and TH than at LS. Higher age, lower body weight were associated with lower BMD. The decrease in BMD was highest in patients with PTHi (100 pg/ml.
B.04 Guest lecture
COBISS.SI-ID: 4070207The following paper describes causes and consequences of vitamin D deficiency in haemodialysis patients. There are recommendations concerning evaluation of vitamin D stores. According to vitamin D levels there are guidelines for assessment and diagnosis of degree of vitamin D deficiency. At the end there are recomendations for vitamin D supplementation.
B.04 Guest lecture
COBISS.SI-ID: 4070463We show the difference between coronary calcification score in diabetic patients treated with hemodialysis and the rest of the patients.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 3906111Invited lecture on Medical Faculty in Aachen
B.04 Guest lecture
COBISS.SI-ID: 3639103Invited lecture at meeting for Baltic countries nephrologists, Riga
B.04 Guest lecture
COBISS.SI-ID: 3876927