Project team members were supervisers of students team from the Univ. of Ljubljana, who successfully completed research project from the field of synthetic biology. Our project won a gold medal at the international competition (iGEM2009) held at the MIT. Our project presented a new technology for the preparation of bionanomaterials from proteins. We prepared and tested modular genetic building blocks to create self-assembling material which could form structures unseen in nature. We represented our work in the field of synthetic biology in the National Assemby of the Republic of Slovenia.
B.04 Guest lecture
COBISS.SI-ID: 4187674Protein gp120 at the external side of HIV-1 plays a leading role in the entry of the virus into the cells. The peptide derived from the V3 domain of gp120 and gp120 bind lipid A (conserved part of the LPS). The structure of the V3 peptide bound to LPS was determined with NMR: the pattern is similar to the one observed with antimicrobial peptides that neutralize LPS. Interaction between LPS and gp120 inhibited binding of gp120 with receptors at the surface on target T cells. Antagonistic nonendotoxic lipid A derivatives inhibited HIV-1 pseudovirus infection of T cells
B.03 Paper at an international scientific conference
COBISS.SI-ID: 4267802