Based on recent studies showing that oxidative stress affects the development of osteoporosis, we are focused on the glutathione peroxidase (GPX1), which protects the bone cells from oxidative damage. It is the first time demonstrated that GPX1 gene polymorphisms with known effects on the reduced enzyme activity are significantly associated with lower levels of bone mineral density and higher concentrations of biochemical markers of bone remodeling. The results represent a significant contribution to the study of the impact of oxidative stress mechanisms in the pathogenesis of osteoporosis.
COBISS.SI-ID: 2864497
RANK/RANKL/OPG system is important regulator of bone resorption. TNFRSF11A gene, encoding RANK, was proved to be associated with osteoporotic fractures in genome-wide studies. The aim of our study was to evaluate the influence of four polymorphisms (670G>C, +34694C>T, +34901G>A, +35966insdelC) in RANK gene on BMD. Besides the significant influence of +35966insdelC on BMD, we were also among the first to show the impact of gene-gene interactions in RANK/RANKL/OPG system as combination of RANK/RANKL (+34901G>A/-290C>T) and RANK/OPG (+35966insdelC/K3N) polymorphisms showed influence on BMD.
COBISS.SI-ID: 2701425