In order to identify osteoporotic genes, the genome-wide gene expression analysis was employed. After biostatistic analysis, list of 1606 genes differently expressed in osteoblasts from osteoporotic as compared to osteoblasts from non-osteoporotic tissue was prepare. Our results present a novel list of genes and metabolic pathways that may be associated with the pathogenesis of osteoporosis. In the next stage, we tested one of this metabolic pathways: genes encoding proteins involved in antioxydative defense in OB was evaluated by in vitro experiments on HOS cell lines after treating with H2O2
COBISS.SI-ID: 2678385
The development of osteoporosis is infulence by numerous genes. One of the most important genes are also genes VDR, OPG and TNFSF11. In our study, the polymorphisms in these genes were analyzed individually and in combinations. 641 individuals were involved in the study. Polymorphisms in VDR, OPG and TNFSF11 genes were found to be important for the development of osteoporosis, individually and in combinations. For the first time, the presence of gene-gene interactions between VDR, OPG and TNFSF11 genes was studied, but their combined influence needs to be further confirmed.
COBISS.SI-ID: 2520689