Using a rodent model with ablated tryptophan-hydroxylase-1, which lacks peripheral serotonin, authors showed that similar to platellets in the blood, also pancreatic beta-cells require the presence of serotonin and covalent modification (serotonylation) of key proteins in the process of exocytosis, is crutial for correct insulin release.
COBISS.SI-ID: 63941377
In pancreatic acinar cells authors conclude that mathematical models should take stochasticity explicitly into account when describing intra- and intercellular processes.
COBISS.SI-ID: 13698582