Keratins, the major structural protein of all epithelia provide structural support to keratinocytes and maintain the integrity of the skin. Amongst the 54 known functional keratin genes in humans, about 22 different genes including, the cornea, hair and hair follicle-specific keratins have been implicated in a wide range of hereditary diseases. This review summarizes and discusses the clinical, ultrastructural, molecular genetics and biochemical characteristics of a broad spectrum of keratin-related genodermatoses, with special clinical emphasis on EBS, EI and PC.
COBISS.SI-ID: 27780057
Four decades have passed since the first recombinant protein, somatostatin, was produced in Escherichia coli. To date, more than 160 biopharmaceuticals gained medical approval. For a long time IB formation represented a problem in protein production. Recent studies reveal that friendlier bacterial cultivation leads to production of non-classical IBs (ncIBs), composed of properly folded and biologically active proteins. Such active ncIBs can be used either for protein isolation (production) or as active nanoparticles, a further development of the use of active IBs is expected.
COBISS.SI-ID: 27780569