In this work, we firstly proposed a structural network as a tool to get an in-depth into complex biological systems. The concept was exemplified on the kallikrein-kinin and the renin-angiotensin systems (KKS-RAS). However, it represents a good model for other biological systems. We found that the CIMR (Cation-independent mannose-6-phosphate receptor repeat) domain links both systems. From the latter, all domain interactors up to level 4 were retrieved, displaying a more comprehensive representation of the KKS-RAS at atomic resolution.
COBISS.SI-ID: 23522087
Neurodegenerative diseases are among conformational disorders, which are characterized by changes in protein conformation and aggregation, thus leading to toxic amyloid oligomers and fibrils. This work critially discusses the main concepts in the field, namely, the "amyloid cascade hypothesis", the "channel hypothesis" and the "metal hypothesis" which focuses on cytotoxic soluble oligomers, their interaction with the cell membranes or the delicate balance of metal ions in the brain.
COBISS.SI-ID: 23129639