Protein-protein interactions define the molecular networks within an organism, whereas a disruption on the later may lead to disease. In this work, we presented a structural and functional network to exemplified this concept on the kallikrein-kinin (KKS) and renin-angiotensin (RAS). The later represent two highly regulated proteolytic systems which participate in several physiological and pathological processes i.e. neurodegeneration, cardiovascular and renal homeostasis, growth and development and inflammation.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 24648743For a long time it was known that proteases were mainly considered as protein degrading enzymes. However, in the last decade this view has significantly changed, and the focus is now on proteases as signalling molecules. In this lecture, it was presented a new view regarding the role of lyosomes and lysosomal proteases in apoptosis and autophagy.
B.04 Guest lecture
COBISS.SI-ID: 25513511Various neurodegenerative disorders involve an anomalous extension of aminoacid residues. In this work we presented a comparison between two proteins and their mutants, namely, ataxin-3 as a model protein with a polyglutamine extension and PABPN1, as a model protein for a polyalanine extension.
B.06 Other
COBISS.SI-ID: 25453863