Histamine was shown to be involved in bone remodeling, the aim of this study was to determine the effects of cetirizine, an H(1) receptor antagonist, on bone modeling . Cetirizine influences bone modeling, mainly by inhibiting bone resorption. Therefore, H(1) receptor antagonists could interfere with different treatment.
COBISS.SI-ID: 28327897
A retrospective immunohistochemical and genetic study on a series of formalin fixed paraffin embedded malignant pleural mesothelioma tissue samples from 101 patients was performed. Survivin expression was assessed immunohistochemically and quantified. Total DNA purification from archival human tissue samples was successfully optimized and the obtained DNA was of high enough yield and quality to ensure robust genotyping of survivin promoter single nucleotide polymorphisms, thus assuring a broader applicability of the isolation method. The study concluded that survivn promoter single nucleotide polymorphisms do not significantly affect survivin expression levels or overall survival in the analysed patient group.
COBISS.SI-ID: 28755673