Expression of leukocyte CD64 has the best diagnostic accuracy for sepsis in critically ill children, while in newborns it is equal to LBP
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COBISS.SI-ID: 28148953In diagnosing of infectious SIRS and severe pneumonia, iCD64 had highest sensitivity, followed by PCT and LBP in blood.
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COBISS.SI-ID: 28149209In infants with severe RSV bronchiolitis requiring ventilation iCD64 and quantitative cultures of aspirates had higher diagnostic accuracy than LBP;PCT and CRP in the blood.
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COBISS.SI-ID: 29235929Abstract Background and Aims Children with temporary external ventricular drains are prone to nosocomial infections. Diagnosis of bacterial ventriculitis in these children is challenging due to frequent blood contamination of cerebrospinal fluid (CSF), presence of chemical ventriculitisand elevation of blood laboratory markers by concomitant bacterial infection. Therefore determination of novel marker of bacterial infection CD64in in CSF seems to be promising. Methods We conducted a prospective, observational pilot study enrolling children with external ventricular drainage at surgical ward and paediatric intensive care unit. CD64in in CSF together with CSF leukocyte count, glucose, proteins and blood leukocyte count, CRP, PCT were studied at the time of suspected ventriculitis.CD64in was measured by flow cytometry (Trillium Diagnostics, LLC, Brewer, ME). Results Ten episodes of clinically suspected ventriculitisin 6 children (male 4, female 2, median age: 9 months, range: 4-167 months) were observed during a 6-month period. Episodes were classified into those with microbiologically proven ventriculitis (5 episodes) and into those with microbiologically negative CSF (5 episodes). CD64in was significantly higher in episodes with ventriculitis in comparison to episodes without ventriculitis (Table). Other blood and CSF markers did not differentiated between groups. Conclusions CD64in might be a useful diagnostic marker of bacterial ventriculitis in children with external ventricular drainage before microbiological confirmation. A larger study is needed in the future.
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COBISS.SI-ID: 441516In newborns after surgery, the level of IL-8 decreases most rapidly ;itis therefore most suitable for diagnosis of postop. infection
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COBISS.SI-ID: 25728985