During our research we developed and characterized biocompatible magnetic nanoparticles that are surface fuctionalized and allow further complexation with active components. These nanoparticles are optimized for intake in cell in in vitro conditions with application of external magnetic fields and exhibit increased uptake in cells with relatively low cytotoxicity. Such nanoparticles are very appropriate vector system for uptake of active components in cells and can be applied in biotechnological anf biomedical applications like magnetofection.
COBISS.SI-ID: 967035
We analyzed magnetic states of agglomerates and evaluated the effect on applicability for biomedical and biotechnological applications. As key finding we showed that magnetic state of agglomerates is determined almost exclusively by state of primary nanoparticles. Hence large agglomerates that exhibit superparamagnetic state like primary nanoparticles are possible whereas response to the external magnetic fields is greatly enhanced. Further, we showed stability of functionalized single-domain nanoparticles and agglomerates and possibility of use for biotechnological applications.
COBISS.SI-ID: 8312660