We developed synthesis procedures and characterized nanoparticles with magnetic core that have multilayer functionalization and are biocompatible. Synthesis procedures allow upgrade of multilayer structure with different macromolecules like DNA; dispersions of such multilyer nanoparticles are stable at physiological conditions. As the magnetic core is agglomerate of nanoparticles, also the response to the external magnetic field is relatively large. Due to flexibility of composition and properties such particles are very appropriate for diverse bioengineering applications.
F.09 Development of a new technological process or technology
COBISS.SI-ID: 34792453Within the project we collaborated with research group from Institute of Oncology Ljubljana on development and optimization of magnetofection method for uptake of DNA in cells with external magnetic field. This method has potentially a number of advantages over alternative methos and could present alternative for viral transfection of lipofection. Specifically for this method we functionalized multilayer magnetic nanoparticles and collaborated on design of magnetofection protocol. We also analyzed different options for optimization of external magnetic system.
F.21 Development of new health/diagnostic methods/procedures
COBISS.SI-ID: 34792709