We report a new method for the synthesis of membrane-permeable and membrane-impermeable biarsenical reagents, which are then used to monitor prion misfolding and internalization. Authors have shown that introduction of tetracystein tag enables differentiation between structures of the protein. The method is used to detect and study protein conformation and for the detection and study of conformational diseases.
COBISS.SI-ID: 4377626
In the publication authors described in detail the functioning of intracellular TLR receptors;TLR3, TLR7, TLR8 and TLR9. Molecular mechanisms of receptors activation and their physiological role were explained. This publication addresses the role of receptors in autoimmune disorders. Authors describe the use of drugs that targeting endosomal TLR receptors.
COBISS.SI-ID: 4351258